Marketed under the trade names Ozempic, Wegovy and Rybelsus, semaglutide is an FDA-approved weight loss pharmaceutical. It is a glucagon-like peptide analog (GLP-1) that has been shown to be very effective in helping overweight clients reach their goal weight. It works by targeting areas of the brain that help regulate appetite. Semaglutide slows gastric emptying, so you feel fuller longer. It is given as a weekly injection in our office.